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. Author manuscript; available in PMC: 2008 Jun 19.
Published in final edited form as: Br J Haematol. 2006 Jan;132(2):216–229. doi: 10.1111/j.1365-2141.2005.05850.x

Fig 6.

Fig 6

TLX1 blocks further development of committed DN thymocytes. (A) DN thymocytes from BALB/c mice were transduced with MSCV-GW or TLX1 and used in FTOC experiments. Two independent experiments were performed and GFP expression was analyzed after 15–18 days. Data represent the mean ± SEM of GFP expression in MSCV-GW- or TLX1 retroviral vector-transduced thymocytes from 8–10 thymi. (B) TLX1 inhibits differentiation of BCL2 transgenic thymocytes. DN thymocytes from a 4 week old BCL2 transgenic mouse were transduced with MSCV-GW, TLX1 or TLX1 N51A for FTOCs. Thymocytes were analyzed after 17 days for expression of GFP and T cell differentiation antigens.