Table 2.
Gross pathology | Histopathology and cytopathology | Molecular pathology |
Erythema | Cellular infiltrate | cytokines (IL-1, IL-6, IL-8, and TNF-α) |
Pain | Separation of cellular layers | Prostaglandins |
Blisters | Apoptosis | Matrix metalloproteinases |
Pseudomembranes | Necrosis | Serine proteases |
Ulcers | Caspase activation | |
Impaired wound healing | DNA adducts | |
Cell cycle arrest | ||
Oxidative stress | ||
Intracellular Ca++ increase | ||
Impaired energy metabolism |