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Percentage of mice developing hind-limb paralysis
| Mouse type | Depletion group | Percent developing paralysis | Mean day post-challenge ± SD |
|---|---|---|---|
| μMT | Control’ | 90.9 | 7.6±0.7 |
| 5B′ + anti-CD4 | 88.9a | 7.6±1.3 | |
| 5B′ + anti-CD8 | 30.0 | 9.0±1.7 | |
| 5B′ + control Ig | 0.0 | -- | |
| BALB/c (WT) | Control’ | 85.7 | 7.5±0.8 |
| 5B′ + anti-CD4 | 57.1b | 8.3±1.3 | |
| 5B′ + anti-CD8 | 0.0 | -- | |
| 5B′ + control Ig | 0.0 | -- |
P = 0.0001 for anti-CD4 v. control Ig, and P = 0.0198 for anti-CD4 v. anti-CD8
P = 0.0147 for anti-CD4 v. control Ig or anti-CD8
