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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: J Autoimmun. 2008 Mar 3;30(4):293–302. doi: 10.1016/j.jaut.2007.12.012

Figure 7. Schematic of proposed mechanism for enhanced generation of iTreg in the presence of rapamycin plus IL-2.

Figure 7

Rapamycin plus IL-2 does not cause (A) preferential proliferation of cells that express FOXP3 upon activation, but instead, causes (B) increased induction of FOXP3 by altered activation followed by proliferation.