Table 3.

Allele frequencies per study-year.

Protein	allele	Allele	All allele	All allele	p-value	1998–99	2003–05	2006
	code	description	freq	count	year-study	allele freq	allele freq	allele freq
CSP	1	7G8	0.6739	93		0.8823	0.5625	0.5357
CSP	2	HB3	0.3043	42		0.0784	0.4375	0.4286
CSP	3	Ven765	0.0217	3		0.0196	0	0.0357
CSP	4	peru1	0.0072	1		0.0196	0	0
p-value testing year-study difference; main observation:					0.0001 ;	CSP allele 1 decreasing
MSP-1-B2	1	K1-126	0.4962	67		0.4898	0.5625	0.463
MSP-1-B2	2	MAD20-144	0.363	49		0.4082	0.25	0.3889
MSP-1-B2	3	K1-99	0.0593	8		0	0.1563	0.0556
MSP-1-B2	4	K1-117	0.0296	4		0	0	0.0741
MSP-1-B2	5	K1-117	0.037	5		0.0816	0	0.0185
MSP-1-B2	6	MAD20-135	0.0074	1		0	0.0313	0
MSP-1-B2	7	K1-81	0.0074	1		0.0204	0	0
K1 total allele count: 85; MAD20 total allele count: 50
p-value testing year-study difference ; main observation:					0.0167 ;	MSP-1-B2 allele 4 increasing
AMA-1	1	3D7	0.8438	108		0.8542	0.8214	0.8462
AMA-1	2	peru1	0.125	16		0.1458	0.1786	0.0769
AMA-1	3	7G8	0.0313	4		0	0	0.0769
p-value testing year-study difference ; main observation:					0.1419;	AMA-1 allele 3 increasing
LSA-1	1	SN	0.7391	102		0.5098	0.7742	0.9286
LSA-1	2	TN	0.2464	34		0.4902	0.2258	0.0357
LSA-1	3	SY	0.0145	2		0	0	0.0357
p-value testing year-study difference ; main observation:					<0.0001;	LSA-1 allele 1 increasing