Fig. 1.
Impact of pharmacological complement 5a receptor (C5aR) targeting on kidney graft survival. Percentage survival rate of mice in each group as a function of post-transplantation time. Group A: 30 min cold ischaemia (CI) in University of Wisconsin (UW) solution (n = 25); group B: 2 h in UW solution without C5aRA (n = 21); group C: 2 h in UW solution with the addition of C5aRA (10−6 M) (n = 21). Pharmacological C5aR targeting improves graft survival rates significantly after 2 h of CI (P = 0·038; log-rank test).