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|
|
QHA | NMA | ||
| Active-capable | Inactive | Active-capable | Inactive | ||
| WT PPARγ-RXR | P467L PPARγ-RXR | WT PPARγ-RXR | P467L PPARγ-RXR | ||
| Lys277 (α4) | Lys259 (α3) | 3.9° | 39.4° | 29.2° | 0.9° |
| Lys259 (α3) | Glu427 (αAF) | 1.8° | 40.2° | 61.8° | 35.8° |
| Lys259 (α3) | Leu424 (αAF) | 1.2° | 37.0° | 79.6° | 104.1° |
| Lys277 (α4) | Glu427 (αAF) | 4.0° | 70.1° | 44.2° | 36.0° |
| Lys277 (α4) | Leu424 (αAF) | 3.0° | 49.2° | 60.3° | 104.1° |
| Leu424 (αAF) | Glu427 (αAF) | 1.3° | 26.6° | 17.9° | 68.7° |
| Average | 2.5° | 48.8° | 48.8° | 58.3° | |
