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Pharmacodynamic results
| PDA closure (n = 57) | Non PDA closure (n = 9) | ||||
|---|---|---|---|---|---|
| Mean | SD | Mean | SD | P | |
| Concentrations comparisons | |||||
| AUC1D (mg l−1 h) | 4620 | 5232 | 1581 | 1352 | 0.02 |
| AUC3D (mg l−1 h) | 5883 | 5865 | 2244 | 1724 | 0.02 |
| Target concentrations | |||||
| AUC1D < 600 mg l−1 h or AUC3D < 900 mg l−1 h | 4 | 4 | 0.006 | ||
| AUC1D > 600 mg l−1 h or AUC3D > 900 mg l−1 h | 53 | 5 | |||
AUC1D, AUC after the first dose; AUC3D, cumulated AUC for the three doses.
