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Observed and predicted AUC increases for CYP3A4 DDIs, where fumic was determined for all compounds by ultrafiltration. (A) Chemical inhibitors, (B) Panvera Vmax ISEF, (C) PanVera Clint ISEF, (D) Gentest Vmax ISEF. Solid line represents line of unity, and dashed lines represent ± two-fold boundaries
