Table 5.

Precision of each of the in vitro approaches (as determined by the root mean square error (RMSE)) at predicting the DDI compared with that of the clinical value

			Precision
	n	Bias Mean error	Root mean square error (RMSE)	Median absolute error (MAE)
All observations
Chemical inhibitors	16	−1.07	4.59	3.97
Gentest Vmax ISEF	20	0.23	2.38	1.32
PanVera CLint ISEF	20	1.79	4.91	1.51
PanVera Vmax ISEF	20	2.71	7.78	1.75
Compounds with free fraction ≥0.1
Chemical inhibitors	11	−2.79	4.82	−2.47
Gentest Vmax ISEF	14	−0.62	2.10	−0.34
PanVera CLint ISEF	14	0.30	3.35	0.23
PanVera Vmax ISEF	14	0.22	2.48	0.58
Compounds with free fraction <0.1
Chemical inhibitors	5	3.66	3.89	4.25
Gentest Vmax ISEF	6	2.20	2.92	2.46
PanVera CLint ISEF	6	5.25	7.36	3.34
PanVera Vmax ISEF	6	8.53	13.70	4.39

Highly bound compounds (fu < 0.1) had fu_mic determined using equilibrium dialysis.