Table 6.
Frequency of categorized predicted DDI values and clinical DDI values, includes highly bound compounds with fumic determined using equilibrium dialysis
| Clinical DDI | ||||
|---|---|---|---|---|
| Prediction | Predicted DDI | ≤2 | >2 | Total |
| Chemical Inhibitors | ≤2 | 2 | 1 | 3 |
| >2 | 3 | 10 | 13 | |
| Total | 5 | 11 | 16 | |
| GENTEST Vmax ISEF | ≤2 | 5 | 0 | 5 |
| >2 | 3 | 12 | 15 | |
| Total | 8 | 12 | 20 | |
| PANVERA Vmax ISEF | ≤2 | 4 | 0 | 4 |
| >2 | 4 | 12 | 16 | |
| Total | 8 | 12 | 20 | |
| PANVERA CLint ISEF | ≤2 | 4 | 0 | 4 |
| >2 | 4 | 12 | 16 | |
| Total | 8 | 12 | 20 | |
Shaded boxes represent number of compounds where predicted DDIs were correctly categorized with the clinical DDIs.