Figure 2.

(A) Mean (±SD) R : S ratios of plasma concentrations following a single oral administration of 60 mg fexofenadine hydrochloride in 12 healthy volunteers after placebo administration (open circles) or itraconazole administration (closed circles). (B) Mean (+SD) cumulative amount of fexofenadine enantiomers excreted into urine during the placebo phase (S-fexofenadine; open circles, R-fexofenadine; open squares) or itraconazole phase (S-fexofenadine; closed circles, R-fexofenadine; closed squares) following a single oral administration of 60 mg fexofenadine hydrochloride in 12 healthy volunteers (S-placebo, (○); S-itraconazole, (•); R-placebo, (□); R-itraconazole, (▪))