Table 2.
AUC (mean values ± SD) at day 1 (Study A and B) and day 6 (Study B) for genotypes
| Study A AUC (mg l−1 h) | *1/*1 (n = 5) | *1/*2 (n = 4) | *1/*17 (n = 1) | *2/*17 (n = 1) | P value *1/*1 vs.*1/*2 |
|---|---|---|---|---|---|
| O10 day 1 | 0.25 ± 0.18 | 0.52 ± 0.31 | 0.14 | 0.41 | 0.141 |
| L15 day 1 | 1.04 ± 0.77 | 1.75 ± 1.05 | 0.47 | 1.39 | 0.282 |
| Study B AUC (mg l−1 h) | *1/*1 (n = 6) | *1/*2 (n = 2) | *1/*17 (n = 6) | *2/*2 (n = 1) | *2/*17 (n = 1) | P-value *1/*1 vs.*1/*17 |
|---|---|---|---|---|---|---|
| O20 day 1 | 0.64 ± 0.34 | 3.42; 1.30 | 0.49 ± 0.22 | 3.44 | 1.06 | 0.365 |
| O20 day 6 | 1.11 ± 0.52 | 5.04; 2.29 | 0.86 ± 0.56 | 4.22 | 2.03 | 0.465 |
| P40 day 1 | 4.56 ± 1.60 | 25.72; 7.16 | 3.42 ± 2.10 | 13.56 | 6.29 | 0.314 |
| P40 day 6 | 4.21 ± 1.91 | 26.87; 8.49 | 3.32 ± 1.33 | 20.71 | 5.95 | 0.374 |