Table 4.

Mean percentage of time (± SD) with intragastric pH > 4 during 24 h for total group and genotypes

Study A	All (n = 11)	*1/*1 (n = 5)	*1/*2 (n = 4)	*1/*17 (n = 1)	*2/*17 (n = 1)
Baseline	13.2 ± 7.4	14.9 ± 9.9	11.9 ± 6.3	13.9	9.5
L15 day 1	34.2 ± 17.3 (P = 0.002*)	35.6 ± 21.1†	38.3 ± 16.4	15.9	29.7
L15 day 6	44.2 ± 15.0 (P < 0.0005*)	43.1 ± 20.1‡	49.4 ± 6.8	26.7	46.1
O10 day 1	22.4 ± 10.9 (P = 0.042*)	19.1 ± 10.1§	29.7 ± 11.5	12.3	19.5
O10 day 6	40.3 ± 20.9 (P = 0.006*)	36.0 ± 20.0¶	46.8 ± 18.8	11.5	64.9

Study B	All (n = 16)	* 1/* 1 (n = 6)	* 1/* 2 (n = 2)	* 1/* 17 (n = 6)	* 2/* 2 (n = 1)	* 2/* 17 (n = 1)
Baseline	13.5 ± 6.1	14.0 ± 5.5	10.7; 15.3	14.5 ± 8.1	6.1	13.0
O20 day 1	27.9 ± 16.3 (P = 0.003*)	20.4 ± 8.9††	48.1; 62.5	21.5 ± 13.4	35.3	48.6
O20 day 6	51.3 ± 16.6 (P < 0.0005*)	50.2 ± 21.0‡‡	62.2; 61.9	47.3 ± 17.3	47.7	62.0
P40 day 1	31.4 ± 14.6 (P = 0.001*)	31.5 ± 10.3§§	50.9; 55.8	20.9 ± 12.8	43.7	37.4
P40 day 6	47.8 ± 16.4 (P < 0.0005*)	44.5 ± 11.9¶¶	68.1; 62.0	46.1 ± 20.8	59.8	30.3

^*P values: compared with baseline.

^†P value *1/*1 vs. *1/*2 after logit-transformation: 0.627,

^‡0.602,

^§0.289,

^¶0.532.

^††P value *1/*1 vs. *1/*17 after logit-transformation: 0.981,

^‡‡0.822,

^§§0.204,

^¶¶0.900.