Figure 3.

(A) Schematic illustration of the two DNA-bound stereoisomers of AP-1 bZip heterodimers bearing the B42 activation domain linked to Fos. (B and C) β-galactosidase gene reporter assays using constructs having either two or one consensus AP-1 sites, respectively. Dyad refers to the oreintation of the central G•C base pair, which is the same for both sites in Fig. 3B. The identity of the base on the coding strand is denoted. Orientation is as given in Fig. 3A: n, mixture of both orientations; U, upstream; D, downstream.