Table 2.
TCR vaccination inhibits neuroantigen but not recall antigen response
| Antigen responses (proliferation) | ||||
|---|---|---|---|---|
| Recall antigens (HSV/TT) [no. positive/total wells (%)] | Neuroantigen peptides (MBP/MOG) [no. positive/total wells1 (%)] | |||
| Subject no. | Entry | Exit | Entry | Exit |
| 5120 | 56/60 (93) | 29/30 (97) | 0/60 (0) | 0/30 (0) |
| 5121 | 60/60 (100) | 30/30 (100) | 0/60 (0) | 0/30 (0) |
| 5122 | 30/30 (100) | 50/50 (100) | 0/30 (0) | 0/50 (0) |
| 5124 | 39/40 (98) | 30/30 (100) | 0/40 (0) | 0/30 (0) |
| 5126 | 30/30 (100) | 30/30 (100) | 12/30 (40) | 1/30 (3)*** |
| 5127 | 30/40 (75) | 30/30 (100)** | 16/40 (40) | 1/30 (3)*** |
| Sum | 245/260 (94) | 199/200 (100)** | 28/260 (11) | 2/200 (1)*** |
| Mean +mn; SD (%) | 94 +mn; 4 | 100 +mn; 1 (NS2) | 13 +mn; 8 | 1 +mn; 1 (NS2) |
1
Background subtracted.
2
Paired t-test.
Asterisks indicate significant change at exit (Fisher's exact test or χ2 test;
**
P < 0·01;
***
P ≤ 0·001).
HSV, herpes simplex virus; MBP, myelin basic protein; MOG, myelin oligodendrocyte glycoprotein; NS, not significant; SD, standard deviation; TT, tetanus toxoid.