Figure 8.

Amino acid sequences of genes encoding antibodies in the sorted 2G10⁺ Gal⁺ and CD11b⁺ population of rhesus monkeys mounting an active immune response to porcine hearts (monkey D11 sequences 2, 3 and 4) are compared with the sequence of immunoglobulin variable-region heavy chain (IgV_H) genes encoding xenoantibodies identified in cDNA libraries made from peripheral blood B cells at day 11 (heart VH311 D11) post-transplantation with porcine heart (a) and porcine islet cells (b).²⁰ The sequence of genes encoding xenoantibodies in the peripheral blood of humans exposed to porcine cells in a bioartificial liver is shown as human BAL.¹⁹ CDR, complementarity determining region; FR, framework.