Figure 2.

Inhibition of cathepsin X increases the proliferation of PBMC induced with PHA. In order to show any possible effect of cathepsin X activity on β₂ integrin dependent PBMC proliferation, PHA, which exerts its action via β₂ integrin receptors, was used to induce the proliferation of PBMC. The FSC–SSC (side scatter) density plot shows a marked increase of proliferating blast cells in the presence of the cathepsin X neutralizing 2F12 mAb relative to control cells stimulated in the absence of inhibitor. R1 indicates the percentage of the proliferating cell population. One representative experiment out of three is presented.