Figure 4.

Effect of inhibitor binding rate on the frequency of the Goldbeter oscillator and on the phase shift between the inhibitor-cyclin complex and free cyclin concentrations. Model parameters are the same as given in Fig. 2 except for K₁ = K₂ = 0.1. For the dashed curves, v_s = 0. (A) The rate of inhibitor binding is rapid, the phase shift is nearly nonexistent, and the oscillations are slowed. Parameter values for the inhibitor are: v_s = 0.2 min⁻¹, K_d = 1.0, and (a₁ + a₂) = 1.0 min⁻¹. (B) The rate of inhibitor binding is slow, the phase shift is large, and the frequency of oscillations is increased. Parameter values for the inhibitor are: v_s = 0.2 min⁻¹, K_d = 1.0, and (a₁ + a₂) = 0.1 min⁻¹.