Table 3.
Recurrent Small Regions of Monoallelic Loss.
| Genomic Localization (I) | Patients with More Than One SNP Deleted (II) | Genes Disrupted (III) | Patients with a Single SNP Deleted at the Genomic Locus (IV) | Genes Potentially Disrupted (V) |
| Chr 1: 239.498.674–240.013.390 | 18% | FH, KMO, OPN3, CHML | 32% | RGS7, WDR64 |
| Chr 4: 155.360.637–155.520.387 | 9% | 5% | DCHS2 | |
| Chr 6: 157.688.569–157.890.930 | 27% | 14% | ZDHHC14 | |
| Chr 6: 162.491.313–163.442.156 | 5% | PARK2 | 5% | PACRG |
| Chr 8: 13.155.237–13.746.870 | 5% | 14% | DLC1 | |
| Chr 9: 8.149.670–8.258.198 | 5% | 5% | PTPRD |
The table compiles a number of recurrent small deletions that lead to a loss of a gene or parts of it.
Localizations (I) denote the mapping according to the 2007 freeze of the human genome (NCBI build 36.2). Column II indicates patients where, in at least three consecutive SNPs, a loss (ratios <1.0 in the log2 scale) could be stated. These index deletions cover at least three SNPs but could be longer. Column III specifies genes that are affected by the index deletion. Column IV denotes patients with deletion for at least one SNP in the region of the index deletion. Column V specifies genes that are located between the index deletion and the next SNP enclosing it and are potentially disrupted. The deletion on chromosome 6 covers genes (PARK2 and PACRG) with inferred function as tumor suppressor, which are also covered by a minimal overlapping region listed in Table 2.