. Author manuscript; available in PMC: 2008 Jun 20.

Published in final edited form as: Am J Psychiatry. 2007 Jan;164(1):43–51. doi: 10.1176/appi.ajp.164.1.43

Table 1.

SPM results of the monetary reward effect (45¢ or 1¢ > 0¢) in all subjects (A: comparison subjects, N=13, and cocaine abusers, N=16) and in direct group comparisons (B: comparison subjects > cocaine abusers). Statistical thresholds were p<0.005 uncorrected for A and p<0.05 uncorrected for B (third order analyses and a priori hypothesis), minimum cluster size was 5 contiguous voxels (135 mm³). Side (hemisphere) and Brodmann’s areas (BA) are listed in the left column; Talairach coordinates, size (number of voxels), T values, and p values (cluster level corrected) are also provided. The average signal in regions in boldface is used for the ROI analyses in Figures 2–3.

	(A) Voxel-by-voxel: All subjects				(B) Voxel-by-voxel: Comparison subjects > Cocaine subjects

Region	x, y, z	Size¹	T	p	x, y, z	Size¹	T	p

PREFRONTAL CORTICAL

1. Left Orbitofrontal Cortex, insula, amygdala BA 47, 13	1. −39,12, −15	114	4.7	.000	−36,18, −9	579	3.1	0.000
	2. −36,6, −3		3.9
	3. −27, −3, −15		2.6^°
2. Right Orbitofrontal Cortex, insula BA 11, 47, 13, 45, 44	4. 39,33, −12	10	4.0	.002^*	30,24,6	554	3.6	0.000
	5. 39,12, −12		2.8^°		48,12,18		3.2
	6. 42,39,0		2.7^°		57,18,6		3.1
	7. 42,21, −12		2.5^°		33,18,12		3.2
					42,12,3		3.2
3. Lateral Prefrontal Cortex BA 10, 9	8. −36,48,18	106	4.8	.005	−27,39,24	579	3.2	0.000
	9. −18,51,33		3.3
	10. 30,45,27		2.8^°
4. Anterior Cingulate Cortex, rostral dorsolateral PFC BA 9, 32, 10	11. 3,45,21	8	3.9	.003^*
	12. 3,54,36		2.9
	13. 6,57,33		3.0
	14. −6,51,12		3.5
	15. 0,48,18		3.1
Other: Right Precentral Gyrus BA 6, 9					48,3,36	554	4.1	0.000
Other: Right Precentral Gyrus BA 6, 9					42, −6,57	554	3.2	0.000

SUBCORTICAL

5. Right Mesencephalon	16. 3, −18, −9	196	4.5	.000
5. Right Mesencephalon	17. 6, −21, −18	196	3.2	.000
6. Left Mesencephalon	18. −12, −18, −3	196	3.8	.000
6. Left Mesencephalon	19. −15, −12, −6	196	3.3	.000
7. Thalamus	20. −6, −9,6	196	4.4	.000	−6, −6,12	310	4.3	0.008
7. Thalamus	21. 18, −12,6	196	3.5	.000	−12, −30,0	310	3.4	0.008
8. Left Cerebellum/Occipital (fusiform, cuneus) BA 18, 19, 31, 37		188		.000	−27, −72, −30	1012	4.3	0.000
					−18, −69, −27		4.1
					−24, −78, −12		5.2
	22. −33,60, −18		5.1		−39, −63, −15		4.4
	23. −30, −45, −30		4.0		−24, −81,24		3.2
					−24, −90,15		3.1
					−27, −84,21		3.0
9. Right Cerebellum/Occipital BA 19		14		.001^*	21, −54, −42	361	4.1	0.003
					30, −57, −42		4.1
	24. 6, −66, −27		3.7		33, −78, −15		3.4
	25. 3, −84,3		3.6		15, −84, −24		3.3
					36, −51, −30		3.2
					9, −69, −36		3.0

Number of voxels;

^°

p<0.05 uncorrected, voxel level, included for complete description of activated cluster;

with small volume correction (5 mm).