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Anticipated effects of different TRAIL resistance mechanisms on sensitivity to different therapeutic agonists.
| Resistance Mechanism | Expected response to Apo2L/TRAIL | Expected response to lexatumumab (anti-DR5) | Expected response to maptumumab (anti-DR4) |
|---|---|---|---|
| DR5 mutation | No apoptosis | No apoptosis | Apoptosis |
| Caspase-8 silencing | No apoptosis | No apoptosis | No apoptosis |
| Increased XIAP | No apoptosis | No apoptosis | No apoptosis |
| Increased DcR2 | No apoptosis | Apoptosis | Apoptosis |
