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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Int J Radiat Biol. 2008 Jun;84(6):487–497. doi: 10.1080/09553000802078396

Table I.

Histological Scoring. The results of blinded scoring using a semiquantitative scale. Acute and chronic changes in the vascular compartment and the airways were scored as follows- 0: absence of histological changes; 1: parenchymal alterations in 1 to 25% of the tissue examined; 2: parenchymal alterations in 26 to 50% of the tissue examined; 3: parenchymal alterations in 51 to 75% of the tissue examined; 4: parenchymal alterations in 76% to 100% of the tissue examined. The 1st and 2nd columns show the time after irradiation and the specific changes and compartments scored respectively. The figures represent mean scores ± sem for each compartment (n=7–10).

Time PI Compartment - Characteristic 0 Gy Mean±sem 5 Gy Mean±sem 10 Gy Mean±sem
3 days Acute Vascular changes - Perivascular edema 0.67±0.17 0.5±0.26 1.3±0.36
2 wks Acute Vascular changes - Perivascular edema 0.55±0.22 0.3±0.16 1±0.32
4 wks Acute Vascular changes - Perivascular edema 0.63±0.32 0.88±0.29 1.63±0.41
8 wks Acute Vascular changes - Perivascular edema 0.4±0.22 1.38±0.32 0.4±0.26
Chronic vascular changes- Vessel wall hyalinization, perivascular fibrosis 1.1±0.27 1.38±0.32 1.2±0.36
20 wks Acute Vascular changes - Perivascular edema 0 0 0
Chronic vascular changes- Vessel wall hyalinization, perivascular fibrosis 0.6±0.22 1±0.43 1.13±0.22
52 wks Acute Vascular changes - Perivascular edema 0.22±0.14 - 0.88±0.35
Chronic vascular changes- Vessel wall hyalinization, perivascular fibrosis ±0.33 - 1.25±0.36
Chronic Airway changes- mononuclear cells 0.78±0.36 - 0.88±0.35