Table 1.
In vivo tumorigenicity of PC cells transfected with antisense PCDGF cDNA and with empty vector
| Cells injected | Day of appearance ±SD | Mice with tumors | Weight, g, ±SD |
|---|---|---|---|
| AS-II1 | — | 0/5 | — |
| AS-II18 | — | 0/5 | — |
| AS-II15 | 36 ± 14 | 2/5 | 0.35 ± 0.05 |
| P14 | 15 ± 3 | 5/5 | 5.4 ± 2.0 |
| P6 | 15 ± 9 | 5/5 | 3.6 ± 1.9 |
| PC | 15 ± 4 | 5/5 | 6.4 ± 2.6 |
C3H female mice were injected s.c. with 106 cells from PCDGF antisense cDNA transfectants (AS-II1, AS-II18, and AS-II15), control transfectants (P14, P6), or nontransfected PC cells. Average day of tumor appearance, number of mice (of five) with tumors at 40 days, and tumor weight in g ± SD are provided.