Table 2. Differential gene expression in human retinal pericytes exposed to hypoxia.
|
Number |
Accession number |
Description |
SLR |
|
Upregulated genes | |||
| 1 |
NM_000076.1 |
cyclin-dependent kinase inhibitor 1C (p57, Kip2, CDKN1C) |
1.7 |
| 2 |
NM_000963.1 |
prostaglandin-endoperoxide synthase 2 (prostaglandin GH synthase and cyclooxygenase, PTGS2) |
1.43 |
| 3 |
NM_013332.1 |
hypoxia-inducible protein 2 (HIG2) |
1.43 |
| 4 |
BC005254.1 |
Similar to C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced), clone MGC:12289 |
1.4 |
| 5 |
NM_016109 |
PPAR(gamma) angiopoietin related protein (PGAR) |
1.36 |
| 6 |
AF064238.3 |
smoothelin large isoform L2 (SMTN) |
1.26 |
| 7 |
AF022375.1 |
vascular endothelial growth factor |
1.26 |
| 8 |
NM_014883.1 |
KIAA0914 gene product (KIAA0914) |
1.16 |
| 9 |
NM_015675.1 |
growth arrest and DNA-damage-inducible, beta (GADD45B) |
1.13 |
| 10 |
NM_002166.1 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2) |
1.06 |
| 11 |
NM_017606.1 |
hypothetical protein DKFZp434K1210 (DKFZp434K1210) |
1.06 |
| 12 |
BC005127.1 |
adipose differentiation-related protein, clone MGC:10598 |
1.03 |
| 13 |
NM_020142.1 |
NADH:ubiquinone oxidoreductase MLRQ subunit homolog (LOC56901) |
1.03 |
| 14 |
NM_003734.2 |
amine oxidase, copper containing 3 (vascular adhesion protein 1, AOC3) |
1 |
| 15 |
NM_006931.1 |
solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) |
0.96 |
| 16 |
S73751.1 |
acyl CoA:cholesterol acyltransferase |
0.93 |
| 17 |
AL048423.1 |
EST: integrin, beta 5 |
0.9 |
| 18 |
NM_003897.1 |
immediate early response 3 (IER3) |
0.9 |
| 19 |
NM_005195.1 |
CCAATenhancer binding protein (CEBP), delta (CEBPD) |
0.9 |
| 20 |
AL049176 |
DNA sequence from clone 141H5 on chromosome Xq22.1–23. Contains parts of a novel Chordin LIKE protein with von Willebrand factor type C domains. |
0.9 |
| 21 |
NM_020639.1 |
ankyrin repeat domain 3 (ANKRD3) |
0.9 |
| 22 |
NM_002912.1 |
REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta (REV3L) |
0.83 |
| 23 |
NM_000954.1 |
prostaglandin D2 synthase (21kD, brain; PTGDS) |
0.83 |
| 24 |
BC000125.1 |
Similar to transforming growth factor, beta 1, clone MGC:3119 |
0.76 |
| 25 |
AI078167 |
EST: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
0.76 |
| 26 |
NM_005384.1 |
nuclear factor, interleukin 3 regulated (NFIL3) |
0.76 |
| 27 |
NM_019058.1 |
hypothetical protein (FLJ20500), mRNA. RTP801 |
0.73 |
| 28 |
NM_003670.1 |
basic helix-loop-helix domain containing, class B, 2 (BHLHB2) |
0.66 |
|
Downregulated genes | |||
| 1 |
NM_000903.1 |
diaphorase (NADHNADPH, cytochrome b-5 reductase, DIA4) |
-2.16 |
| 2 |
NM_003234.1 |
transferrin receptor (p90, CD71, TFRC) |
-1.53 |
| 3 |
NM_020299.1 |
aldo-keto reductase family 1, member B10 (AKR1B10) |
-1.53 |
| 4 |
NM_018092.1 |
neuropilin (NRP) and tolloid (TLL)-like 2 (NETO2) |
-1.23 |
| 5 |
M21692.1 |
class I alcohol dehydrogenase (ADH2) beta-1 subunit |
-1 |
| 6 |
D45421.1 |
mRNA for phosphodiesterase I alpha |
-0.86 |
| 7 | AK021882.1 | cDNA FLJ11820 fis, clone HEMBA1006445, highly similar to putative tumor supressor NOEY2 | -0.76 |
The transcriptional response of human retinal pericytes to hypoxia was examined by microarray analysis, the SLR (signal-log ratio) is the mean value of three independent experiments.