Table 3.
Results of robust conditional logistic regression analysis to look for association between SNPs on chromosome 5q23.3-q31.1 and three leishmaniasis-related phenotypes (VL, DTH+ and DTH−).
| Label | SNP | Phenotype | Robust Allele- wise Global Test P-value |
Allele | Odds Ratio | 95% CI |
|---|---|---|---|---|---|---|
| D | rs2070874 | DTH+ | 0.382 | C | 1.24 | 0.77 - 2.01 |
| L | rs248158 | DTH+ | 0.005 | G | 2.25 | 1.28 - 3.97 |
| M | rs2526146 | DTH+ | 0.015 | A | 1.65 | 1.10 - 2.47 |
| N | rs2526152 | DTH+ | 0.015 | A | 1.53 | 1.08 - 2.16 |
| O | rs30740 | DTH+ | 0.139 | T | 1.47 | 0.89 - 2.45 |
| R | rs4976360 | DTH+ | 0.003 | T | 1.94 | 1.24 - 3.03 |
| T | rs1054124 | DTH+ | 0.013 | A | 1.91 | 1.15 - 3.18 |
| U | rs4669 | DTH+ | 0.029 | C | 1.69 | 1.06 - 2.71 |
| D | rs2070874 | DTH− | 0.006 | C | 3.14 | 1.38 - 7.14 |
| L | rs248158 | DTH− | 0.281 | G | 1.56 | 0.69 - 3.52 |
| M | rs2526146 | DTH− | 0.408 | A | 1.57 | 0.54 - 4.58 |
| N | rs2526152 | DTH− | 0.202 | A | 1.31 | 0.86 - 1.99 |
| O | rs30740 | DTH− | 0.042 | T | 3.00 | 1.04 - 8.65 |
| R | rs4976360 | DTH− | 0.722 | T | 0.87 | 0.39 - 1.91 |
| T | rs1054124 | DTH− | 0.536 | A | 1.25 | 0.62 - 2.53 |
| U | rs4669 | DTH− | 0.722 | C | 0.89 | 0.49 - 1.65 |
| D | rs2070874 | VL | 0.123 | C | 1.60 | 0.88 - 2.91 |
| L | rs248158 | VL | 0.869 | G | 1.05 | 0.60 - 1.82 |
| M | rs2526146 | VL | 0.881 | A | 1.04 | 0.63 - 1.70 |
| N | rs2526152 | VL | 1.000 | A | 1.00 | 0.64 - 1.55 |
| O | rs30740 | VL | 0.140 | T | 2.33 | 0.76 – 7.19 |
| R | rs4976360 | VL | 1.000 | T | 1.00 | 0.46 - 2.17 |
| T | rs1054124 | VL | 0.794 | A | 1.10 | 0.55 - 2.17 |
| U | rs4669 | VL | 0.874 | C | 0.96 | 0.55 - 1.65 |
Data are shown for 8 of the 18 SNPs analysed (see figure 1) that showed association with at least one phenotype. CI = confidence interval. Bold indicates a significant allele-wise association.