Table 1.

Summary of the species differences of PPARα.

	Human	Rodent
PPARα expression levels	+	++
PPARα variants	Yes	?
Peroxisome proliferation	+/−	+
Fatty acid metabolism	+	+
Expression of cell cycle regulator genes	+/−	+
Expression of miRNA (let-7C)	+	−
Hepatocellular proliferation	+/−	+
Apoptosis	+	−
Liver tumor	+/−	++