Table 4.
Loc (Build 36.2) | Regiona,b | Variant | rs ID | Group | Genotype Counts | Allele Counts (Frequencies) | p-valued | |||
---|---|---|---|---|---|---|---|---|---|---|
Maj/Maj | Het | Min/Min | Major | Minor | ||||||
86 528 755 | Intron 2 | T/A | rs4887380 | Cases | 107 | 62 | 7 | 276 (0.784) | 76 (0.216) | 0.063 |
Controls | 120 | 53 | 3 | 293 (0.832) | 59 (0.168) | |||||
86 528 340 | Intron3 | G/C | rs4887379 | Cases | 100 | 66 | 10 | 266 (0.756) | 86 (0.244) | 0.008 |
Controls | 120 | 53 | 3 | 293 (0.832) | 59 (0.168) | |||||
86 527 590 | Intron 4 | C/T | Novel | Cases | 111 | 59 | 6 | 281 (0.798) | 71 (0.202) | 0.386 |
Controls | 108 | 61 | 2 | 277 (0.810) | 65 (0.190) | |||||
86 489 658 | Intron 5 | A/G | rs6496463 | Cases | 36 | 92 | 45 | 164 (0.474) | 182 (0.526) | 0.048 |
Controls | 55 | 79 | 41 | 189 (0.540) | 161 (0.460) | |||||
86 481 688 | Exon6 | AAC→AAT (synonymous Asn) | rs1128994 | Cases | 94 | 70 | 12 | 258 (0.733) | 94 (0.267) | 0.466 |
Controls | 92 | 76 | 8 | 260 (0.739) | 92 (0.261) | |||||
86 470 386 | Intron 12 | C/G | rs3825882c | Cases | 38 | 93 | 44 | 169 (0.483) | 181 (0.517) | 0.034 |
Controls | 60 | 73 | 41 | 193 (0.555) | 155 (0.445) | |||||
86 392 534 | Intron 12 (cons 6) | G/T | rs28565987 | Cases | 138 | 34 | 2 | 310 (0.891) | 38 (0.109) | 0.431 |
Controls | 141 | 34 | 1 | 316 (0.898) | 36 (0.102) | |||||
86 377 189 | Exon13 | CGC→CGG (synonymous Arg) | rs2229910 | Cases | 67 | 85 | 24 | 219 (0.622) | 133 (0.378) | 0.173 |
Controls | 79 | 74 | 23 | 232 (0.659) | 120 (0.341) | |||||
86 322 455 | Intron 13 (Exon 15 of NTRK3c-3′UTR) | G/A | Novel | Cases | 156 | 17 | 2 | 329 (0.940) | 21 (0.060) | 0.556 |
Controls | 156 | 19 | 1 | 331 (0.940) | 21 (0.060) | |||||
86 322 284 | Intron 13 (Exon 15 of NTRK3c-3′UTR) | G/C | rs28521337 | Cases | 37 | 92 | 47 | 166 (0.472) | 186 (0.528) | 0.530 |
Controls | 41 | 84 | 51 | 166 (0.472) | 186 (0.528) | |||||
86 230 145 | Intron 16 | T/C | Novel | Cases | 152 | 24 | 0 | 328 (0.932) | 24 (0.068) | 0.616 |
Controls | 153 | 21 | 2 | 327 (0.929) | 25 (0.071) | |||||
86 230 080 | Intron 16 | T/C | rs11633200 | Cases | 17 | 86 | 73 | 120 (0.341) | 232 (0.659) | 0.290 |
Controls | 26 | 76 | 74 | 128 (0.364) | 224 (0.636) | |||||
86 224 467 | Intron 18 | G/A | rs1560975c | Cases | 23 | 88 | 65 | 134 (0.381) | 218 (0.619) | 0.630 |
Controls | 23 | 81 | 67 | 127 (0.371) | 215 (0.629) |
Regions are in reference to the NTRK3a transcript except where the NTRK1c transcript is specified.
“cons” refers to highly conserved regions that are numbered in accordance with their location beginning from the 5′ end of NTRK3.
Genotype data from Hap Map project available at www.hapmap.org.
Uncorrected p-values < 0.05 are marked in bold.