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GCN4 bZIP-DNA binding schemes. (A) Dimeric binding of basic regions on DNA full site. Both basic regions of the dimer bind to target DNA half sites selectively. (B) Dimeric binding of basic regions on DNA half site. Only one basic region of the dimer binds selectively to the target DNA half site; the other basic region interacts nonspecifically with DNA. (C) Monomeric binding of basic regions on DNA half site; no protein dimerization occurs.
