Table 1.

Summary of cadherin domain structures included in this study

Family	Protein	Domain	PDB ID	Range	Resolution (Ǻ)	Notes
Type I	E-cadherin	EC1	1FF516	1–99	2.93	non-swapped; non-native extra residue§ (M) at N-terminus
		EC2	1FF5	105–212	2.93
Type I	E-cadherin	EC1	1Q1P21	2–99	3.20	swapped; N-terminal residue disordered
		EC2	1Q1P	105–212	3.20
Type I	E-cadherin	EC1	1EDH15	3–99	2.00	non-swapped; N-terminal 2 residues disordered
		EC2	1EDH	105–212	2.00
Type I	E-cadherin	EC1	2O7223	1–99	2.00	swapped
		EC2	2O72	105–212	2.00
Type I	E-cadherin	EC1	1O6S19	1–99	1.80	in complex with internalin; non-native extra 4 residues (GPLG) at N-terminus and D1S mutation
Type I	E-cadherin	EC1	1SUH13	1–99	NMR	monomeric
Type I	C-cadherin	EC1	1L3W17	1–99	3.08	swapped
		EC2	1L3W	105–212	3.08
		EC3	1L3W	218–324	3.08
		EC4	1L3W	329–431	3.08
		EC5	1L3W	437–540	3.08
Type I	N-cadherin	EC1	1NCI14	2–99	2.10	swapped; non-native extra 2 residues (GS) at N-terminus; D27G mutation
Type I	N-cadherin	EC1	1NCG14	1–99	2.10	swapped; D27G mutation
Type I	N-cadherin	EC1	1NCH14	1–99	2.10	swapped; non-native extra 2 residues (GS) at N-terminus of one chain; D27G mutation
Type I	N-cadherin	EC1	1NCJ27	2–99	3.40	monomeric; N-terminal residue disordered
		EC2	1NCJ	105–214	3.40
Type I (non-swapping)	T-cadherin	EC1	---*	1–98	1.10	non-swapped; A1S mutation
Type I (non-swapping)	T-cadherin	EC1	---*	1–98	2.90	non-swapped; A1S mutation
		EC2		104–216	2.90
Type II	mn-cadherin	EC1	1ZVN22	1–97	2.16	swapped; non-native extra residue (G) inserted between the first two N-terminal residues
Type II	cadherin-11	EC1	2A4C22	1–97	2.90	swapped; non-native extra residue (S) at N-terminus
Type II	cadherin-11	EC1	2A4E22	1–97	3.20	swapped; non-native extra residue (S) at N-terminus
		EC2	2A4E	102–206	3.20
Type II	cadherin-8	EC1	1ZXK22	1–97	2.00	swapped; G1S mutation
Type II	cadherin-8	EC1	2A6222	1–97	4.50	swapped; G1S mutation
		EC2	2A62	103–206	4.50
		EC3	2A62	212–322	4.50
Protocadherin	protocadherin-α4	EC1	1WUZ25	1–98	NMR	monomeric
Protocadherin	protocadherin-α14	EC1	1WYJ**	9–106	NMR	monomeric; non-native extra 7 residues (GSSGSSG) at N-terminus
Protocadherin	protocadherin-7	EC3	2YST**	11–112	NMR	monomeric; non-native extra 6 residues (SSGSSG) and native linker sequence (NDN) at N- terminus
Type I	N-cadherin	prodomain	1OP420	33–124	NMR	monomeric
Desmoglein	desmoglein-2	EC1	2YQG**	11–111	NMR	monomeric; non-native extra 8 residues (GSSGSSGQ) and native protease site (KR) at N-terminus

^§Non-native residues include residues seen in the crystal structure that are not found in the native protein sequence.

^*unpublished

^**to be published; coordinates available from the RCSB Protein Data Bank (http://www.rcsb.org/pdb/)