Table 3.
Dynamic histomorphometry indices of lateral abaxial tibial osteophytes.
| BFR/BS (µm3/µm2/year) |
dLS/BS (%) |
MS/BS (%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| lat abax o.p. | EMC | lat SCB | lat abax o.p. | EMC | lat SCB | lat abax o.p. | EMC | lat SCB | |
| OVX | 6.70 | 11.06 | 3.69 | 2.31 | 1.79 | 0.45 | 7.50 | 3.45 | 8.09 |
| n=16 | (0.00–215.21) | (0.00–69.70) | (0.00–171.48) | (0.00–17.99) | (0.00–10.26) | (0.00–19.32) | (0.00–32.51) | (0.00–17.33) | (0.00–20.30) |
| SPE | 29.71 | 10.77 | 4.51 | 4.05 | 0.87 | 3.11 | 9.32 | 2.43 | 5.93 |
| n=16 | (0.00–719.93) | (0.00–118.66) | (0.00–242.20) | (0.00–20.25) | (0.00–6.51) | (0.00–11.94) | (0.00–29.72) | (0.00–11.32) | (0.00–13.38) |
| ERT | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.28 | 0.28 |
| n=17 | (0.00–151.25) | (0.00–30.40) | (0.00–42.65) | (0.00–14.00) | (0.00–2.67) | (0.00–6.93) | (0.00–24.87) | (0.00–15.31) | (0.00–12.78) |
| p-value | 0.101 | 0.052 | 0.074 | 0.154 | 0.043† | 0.103 | 0.248 | 0.188 | 0.006** |
| MAR (µm/day) | BFR/BV (%/year) | BS/BV (mm/mm2) | |||||||
| lat abax o.p. | EMC | lat SCB | lat abax o.p. | EMC | lat SCB | lat abax o.p. | EMC | lat SCB | |
| OVX | 0.52 | 0.74 | 0.24 | 9.59 | 29.04 | 2.48 | 13.31 | 25.49 | 7.82 |
| n=16 | (0.00–3.84) | (0.00–2.14) | (0.00–2.50) | (0.00–375.83) | (0.00–191.41) | (0.00–196.44) | (7.60–19.41) | (14.28–34.42) | (4.81–12.39) |
| SPE | 0.76 | 0.89 | 0.27 | 31.22 | 25.50 | 3.48 | 13.32 | 25.82 | 7.73 |
| n=16 | (0.00–6.64) | (0.00–2.87) | (0.00–5.80) | (0.00–878.76) | (0.00–219.90) | (0.00–148.21) | (8.68–19.79) | (18.53–31.85) | (3.71–10.49) |
| ERT | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 13.83 | 27.53 | 8.26 |
| n=17 | (0.00–1.67) | (0.00–0.62) | (0.00–2.83) | (0.00–321.15) | (0.00–92.62) | (0.00–38.64) | (8.54–21.77) | (22.60–36.48) | (4.13–11.72) |
| p-value | 0.107 | 0.018* | 0.089 | 0.133 | 0.065 | 0.069 | 0.475 | 0.384 | 0.664 |
data expressed as median values (range)
OVX = ovariectomized control group; SPE = soy phytoestrogen group; ERT = estrogen replacement group
lat abax o.p. = lateral abaxial osteophyte; EMC = epiphyseal-metaphyseal cancellous bone; lat SCB = lateral subchondral bone
dLS/BS = double-labeled surface; MS/BS = mineralizing surface; MAR = mineral apposition rate
BFR/BV = bone formation rate, bone referent; BS/BV = bone surface/volume
significant result; after adjusting for multiple comparisons, the pair-wise comparisons were not statistically significant
significant difference between SPE and ERT treatment groups
significant difference between ERT and both OVX and SPE treatment groups