Table 1.

PAR1 Genes and Protein Function. Only Genes that have been Cloned or Otherwise Characterized are Shown

Gene symbol	Alternative name/symbol	Protein	Ref.
PLCXD1: phospatidylinositol-specific phospholipase C, X domain containing 1	FLJ11323	Function not known.	[70, 71]
GTPBP6: GTP binding protein 6 (putative)	PGPL	Function not known.	[72]
PPP2R3B: Protein phosphatase 2, regulatory subunit B	PPP2R3L, PR48 protein	Exerts regulatory control over the initiation of DNA replication. Over-expression of PR48 causes G1 cell cycle arrest.	[73]
SHOX: short stature homeobox	PHOG, GCFX, SS, SHOXY	Homeobox-containing gene, thought to be a transcription factor related to short stature syndromes.	[34, 36]
CRLF2: cytokine receptor-like factor 2	CRL2, TSLPR	The receptor for TSLP, a cytokine that enhances the maturation process of dendritic cells and promotes the proliferation of CD4+ T cells.	[74–77]
CSF2RA: colony-stimulating factor 2 receptor, alpha	CD116, GMCSFR	The alpha subunit of the receptor for the granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF is important for the growth and differentiation of eosinophils and macrophages in the bone marrow, and also regulates cell viability in human embryos.	[55–57, 78–80]
IL3RA: interleukin 3 receptor, alpha	CD123	The alpha subunit of the receptors for interleukin 3.	[81, 82]
SLC25A6: solute carrier family 25, member A6	ANT3, ANT3Y, MGC17525	A member of the ADP/ATP translocase family, which has a potential role in Th cell survival and immune cell homeostasis.	[83–85]
ASMTL: acetylserotonin O-methyltransferase-like	ASMTLX	Function not known.	[22]
P2RY8: purinergic receptor P2Y, G-protein coupled, 8	P2Y8	A member of the purine nucleotide G-protein coupled receptor gene family.	[86]
CXYorf3	XE7, XE7Y, DXYS155E, MGC39904, B lymphocyte surface antigen 721P, X-escapee, CCDC133	Alternative splicing regulator.	[17, 18, 21]
ASMT: acetylserotonin O-methyltransferase	HIOMT, ASMTY, HIOMTY	Catalyzes the final reaction in the synthesis of melatonin.	[84, 87]
DHRSXY: dehydrogenase/reductase (SDR family) X-linked	DHRS5X, DHRS5XY, DHRSY, DHRS5Y	Encodes an oxidoreductase of the short-chain dehydrogenase/reductase family.	[88]
ZBED1: zinc finger, BED-type containing 1	TRAMP, ALTE, KIAA0785	Has been suggested to be involved in the transposition of other transposable elements.	[89]
CD99: CD99 molecule	MIC2, CD99 antigen, “antigen identified by monoclonal antibodies 12E7, F21 and O13”	Is a cell surface molecule involved in T-cell adhesion processes. Activation of a distinct domain of CD99 activates a caspase-independent death pathway in T-cells.	[90–92]
XG: XG blood group	PBDX, “XG blood group, pseudoautosomal boundary-divided on the X-chromosome”	The blood group gene XG generates a cell-surface antigen 48 % homologues to CD99.	[93, 94]