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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: J Oral Maxillofac Surg. 2008 Apr;66(4):625–631. doi: 10.1016/j.joms.2007.11.032

Table 3.

Chemotherapy and risk of ONJ.

Crude Adjusted

Cancer and Chemotherapy Odds Ratio 95% C.I Odds Ratio 95% C.I

Bevacizumab 5.00 0.70 – 35.50 2.83 0.02 – 463.35
Bone Marrow Transplant 0.63 0.14 – 2.84 0.69 0.10 – 4.62
Busulfan 1.49 0.28 – 7.93 0.50 0.05 – 5.12
Capecitabine 19.56* 2.24 – 171.02 1.08 0.07 – 16.42
Carboplatin 2.76 0.29 – 26.53 4.66 0.00 – 5.08e+08
Cyclophosphomide 0.77 0.30 – 1.98 0.79 0.17 – 3.67
Docetaxel 5.79 0.91 – 36.92 0.70 0.00 – 10801.39
Doxorubicin 0.90 0.30 – 2.74 0.54 0.09 – 3.34
Etoposide 2.24 0.11 – 44.88 0.48 0.00 – 43839.61
Gemcitabine 6.22* 1.50 – 25.68 2.87 0.17 – 48.50
Interferon 0.80 0.08 – 8.04 0.02 0.00 – 97805.93
Melphalan 0.77 0.23 – 2.63 0.56 0.11 – 2.81
Methotrexate 0.42 0.05 – 3.90 0.62 0.02 – 23.71
Paclitaxel 6.34* 1.47 – 27.34 23.54 0.30 – 1867.83
Statin 1.66 0.70 – 3.96 2.26 0.60 – 8.52
Steroid High Dose 0.35 0.10 – 1.22 0.56 0.08 – 3.81
Steroid Low Dose 3.28* 1.44 – 7.51 0.72 0.18 – 2.84
Tamoxifen 1.73 0.38 – 7.74 0.88 0.05 – 16.59
Thalidomide 2.40 0.68 – 8.54 1.97 0.39 – 10.04
Trastuzumab 2.50 0.23 – 27.57 67.95 0.35 – 13140.06
Vinorelbine 23.40* 2.75 – 199.31 109.70 0.38 – 31679.47
*

p<0.05

adjusted for metastasis, zoledronate, obesity, and smoking