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. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: FEBS Lett. 2008 Apr 7;582(10):1514–1518. doi: 10.1016/j.febslet.2008.03.046

Fig. 4.

Fig. 4

570-600Δ TRPY1 fails to respond to Ca2+ and applied stretch force but can be activated by indole (Top trace) In a patch excised from a wild-type vacuole, two conducting units were inactive activated by 10-5 M Ca2+, and further activated by the exertion of 120 mm Hg pressure (left). Addition of 10-3 M Ca2+ activated the two units nearly completely, such that the additional effect of applied pressure was not evident (right). (Bottom trace) In a comparable experiment with a patch excised from a 570-600Δ Yvc1 vacuole, no channel activities could be elicited with 10-5 M Ca2+ and pressure (left), or even with 10-3 M Ca2+ and pressure (right). Addition of 2 mM indole clearly activated a unitary conductance in this patch.