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Other aromatic compounds also activate TRPY1 channel. (A) Structures of the various aromatics tested. (B) Para-propylbenzoate (propylparaben) (first arrow) potentiated the Ca2+ release induced by osmotic upshock (second arrow) in wild-type cells (left). This release was not observed in the yvc1Δ mutant (right). Same procedure as in Fig. 1. (C) Para-propylbenzoate reversibly activated a wild-type TRPY1 conductance in an excised patch bathed in 10-7 M Ca2+.
