3.

Incidence rates of verified first MI in nonresponders and responders to anti-TNFα treatment^*

	Nonresponders (n = 1,638)	Responders (n = 5,877)
Person-years	1,815	9,886
No. of reported MIs	17	35
Rate of MIs per 1,000 person-years (95% CI)	9.4 (5.5–15.0)	3.5 (2.5–4.9)
Incidence rate ratio	Referent	0.38 (0.21–0.67)
Incidence rate ratio, adjusted for age and sex	Referent	0.38 (0.22–0.68)
Incidence rate ratio, multivariate analysis†	Referent	0.36 (0.19–0.69)
Incidence rate ratio by sex, multivariate analysis†
Male patients	Referent	0.31 (0.12–0.81)
Female patients	Referent	0.46 (0.20–1.06)

^*95% CI = 95% confidence interval (see Table 1 for other definitions).

^†Adjusted for age, sex, disease severity, body mass index, social deprivation, smoking history, comorbidity, and baseline drug use.