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. Author manuscript; available in PMC: 2008 Jun 23.
Published in final edited form as: Int J Oncol. 2008 Mar;32(3):625–631.

Figure 1.

Figure 1

Growth and morphological effects of ATRA treatment of HL60 cells. (A) Morphological changes in HL60 cells treated with 2 μM all-trans retinoic acid. Photographs were taken at magnification x200. Cells treated with 2 μM ATRA become larger and more internally complex as they differentiate into granulocytes. Clumping begins on day 6 and is dominant by day 12 of ATRA treatment. (B) Effects of 2 μM all-trans retinoic acid on HL60 proliferation. Cells were counted on a hemocytometer after trypan blue exclusion staining. Bars represent standard error of the mean from three separate experiments.