Table 2.
Performance on the cognitive tasks for estradiol and placebo treatments on the cholinergic placebo challenge day with standard errors. A significant effect of age is indicated.
| Cognitive Construct | Task | Dependent Variable | Age Group | E2 | PLC |
|---|---|---|---|---|---|
| Attention | |||||
| CFF | |||||
| Total (Hz) | Young | 28.69 (.9) | 29.13 (.7) | ||
| Old | 27.70 (.9) | 28.20 (.7) | |||
| Ascending (Hz) | Young | 28.79 (1.2) | 29.12 (.6) | ||
| Old | 26.77 (1.2) | 27.80 (.6) | |||
| Descending (Hz) | Young | 28.75 (.8) | 28.80 (.8) | ||
| Old | 28.52 (.8) | 28.64 (.8) | |||
| CRT | |||||
| Total (ms) | Young | 734.86 (26.9) | 742.12 (26.9) | ||
| Old | 811.62 (26.7) | 832.92 (26.9) | |||
| Recognition RT (ms) | Young | 423.63 (19.7) | 424.85 (19.7) | ||
| Old | 455.25 (19.7) | 447.73 (19.7) | |||
| Motor RT (ms)1 | Young | 301.30 (19.8) | 310.07 (19.8) | ||
| Old | 368.33 (19.8) | 378.46 (19.8) | |||
| CPT | |||||
| Hits (proportion correct) | Young | 35.94 (2.3) | 39.64 (.3) | ||
| Old | 38.00 (2.2) | 39.18 (.3) | |||
| Errors of Omission (number of errors) | Young | 4.06 (2.3) | .36 (.3) | ||
| Old | 2.00 (2.2) | .73 (.3) | |||
| Errors of Comission (number of errors) | Young | .09 (.2) | .45 (.4) | ||
| Old | .82 (.2) | .82 (.4) | |||
| Hit RT (ms) | Young | 463.27 (28.5) | 468.94 (28.1) | ||
| Old | 476.49 (28.1) | 502.76 (28.1) | |||
| Verbal Memory | |||||
| SRT | |||||
| Total Recall (number correct) | Young | 78.36 (3.5) | 81.18 (3.5) | ||
| Old | 72.45 (3.5) | 68.64 (3.5) | |||
| Recall Consistency (number correct) | Young | 39.82 (4.2) | 44.36 (4.2) | ||
| Old | 34.36 (4.2) | 30.55 (4.2) | |||
| Recall Failure (number of failures) | Young | 12.64 (2.7) | 12.09 (2.7) | ||
| Old | 18.00 (2.73) | 20.64 (2.73) | |||
| PR | |||||
| NYU Scoring (percent correct) | Young | .40 (.05) | .39 (.05) | ||
| Old | .32 (.05) | .28 (.05) |
1
Main effect of Age for Motor RT: F(1,20) = 5.88, p < .05