Table 3.
Performance differences for cognitive tasks for each drug challenge by treatment type and age group with standard errors. Numbers represent difference scores (cholinergic drug minus placebo). Significant effects of estradiol treatment and age are indicated. See text for cholinergic challenge effects.
| Cognitive Construct | Task | Dependent Variable | Age Group | 2.5 µg/kg SCOP + E2 | 2.5 µg/kg SCOP + PLC | 20 mg MECA + E2 | 20 mg MECA + PLC |
|---|---|---|---|---|---|---|---|
| Attention | |||||||
| CFF | |||||||
| Total (Hz) | Young | −.76 (.73) | −1.45 (.52) | 1.77 (1.05) | .81 (.51) | ||
| Old | −.72 (.76) | −.62 (.52) | 1.39 (1.05) | 1.11 (.54) | |||
| Ascending (Hz) | Young | −.55 (.96) | −1.03 (.60) | 1.37 (.60) | .28 (.60) | ||
| Old | .31 (1.0) | −.42 (.60) | .33 (.60) | .88 (.63) | |||
| Descending (Hz) | Young | −1.35 (.62) | −1.54 (.62) | .44 (.55) | .26 (.55) | ||
| Old | −1.47 (.62) | −1.04 (.62) | .35 (.55) | .47 (.58) | |||
| CRT | |||||||
| Total (ms) | Young | 43.73 (26.1) | 22.95 (26.1) | 11.31 (25.9) | 39.23 (25.5) | ||
| Old | 39.56 (26.1) | 65.51 (26.1) | 86.51 (25.9) | 30.32 (25.8) | |||
| Recognition RT (ms) | Young | 11.83 (15.5) | 19.64 (15.5) | 2.53 (12.0) | −1.75 (14.2) | ||
| Old | 16.37 (15.5) | 41.24 (15.5) | −15.56 (13.4) | −1.44 (12.6) | |||
| Motor RT (ms) | Young | 18.24 (20.2) | −8.77 (20.2) | 14.38 (20.1) | 25.07 (20.1) | ||
| Old | −5.35 (20.2) | 16.81 (20.2) | 61.03 (20.1) | 29.56 (20.1) | |||
| CPT | |||||||
| Hits (proportion correct) | Young | −2.89 (2.4) | −5.18 (1.5) | −.01 (1.38) | −.55 (.4) | ||
| Old | .86 (2.4) | −1.49 (1.5) | 0.82 (1.26) | .18 (0.4) | |||
| Errors of Omission (number of errors) | Young | 2.89 (2.4) | 4.91 (1.5) | −.21 (1.4) | .55 (.4) | ||
| Old | −.89 (2.4) | 1.58(1.5) | −.91 (1.3) | −.18 (.4) | |||
| Errors of Comission (number of errors) | Young | 1.3 (0.5) | .91 (.5) | .85 (.4) | −.27 (.3) | ||
| Old | .10 (0.5) | 1.10 (.5) | −.27 (.3) | .18 (.3) | |||
| Hit RT (ms) | Young | 52.49 (18.2) | 12.29 (17.3) | 22.46 (19.3) | 18.99 (17.4) | ||
| Old | −14.49 (18.2) | −43.90 (18.2) | 7.78 (17.4) | −8.48 (17.4) | |||
| Verbal Memory | |||||||
| SRT | |||||||
| Total Recall (number correct)1 | Young | −13.55 (3.6) | −20.00 (3.6) | −2.64 (2.7) | −7.18 (2.7) | ||
| Old | −16.00 (3.6) | −7.55 (3.6) | −5.73 (2.7) | −2.55 (2.7) | |||
| Recall Consistency (number correct)2 | Young | −11.91 (3.6) | −19.9 (3.6) | −1.45 (3.1) | −8.36 (3.1) | ||
| Old | −15.73 (3.6) | −5.73 (3.6) | −6.54 (3.1) | −2.18 (3.1) | |||
| Recall Failure (number of failures)3 | Young | 11.08 (2.9) | 16.82 (4.1) | 3.01 (2.4) | 3.73 (2.4) | ||
| Old | 13.00 (2.9) | 7.00 (4.1) | 3.36 (2.4) | 3.00 (2.4) | |||
| PR | |||||||
| NYU Scoring (number correct) | Young | −.15 (0.04) | −.05 (.07) | −.05 (0.1) | .01 (.1) | ||
| Old | −.02 (0.04) | .05 (.07) | .003 (.1) | .07 (0.1) |
1
SCOP analysis age and treatment interaction for total recall: F(1,20) = 10.73, p < .01
2
SCOP analysis age and treatment interaction for recall consistency: F(1,20) = 17.44, p < .001
3
SCOP analysis age and treatment interaction for recall failure: F(1,20) = 5.57, p < .05