Table 5.
Vital signs difference scores with standard errors. The maximum change from baseline for each measure was calculated. Next measures from the placebo cholinergic challenge day were subtracted from each study drug day rating. Significant effects of estradiol treatment and age are indicated
| Vital Signs | Age Group | 2.5 µg/kg SCOP + E2 | 2.5 µg/kg SCOP + PLC | 20 mg MECA + E2 | 20 mg MECA + PLC |
|---|---|---|---|---|---|
| Systolic Blood Pressure (mmHg) | |||||
| Young | 4.09 (11.6) | 9.55 (11.1) | 5.18 (10.6) | 18.18 (10.6) | |
| Old | 17.45 (11.3) | 4.82 (11.1) | 28.55 (10.6) | 29.27 (10.6) | |
| Diastolic Blood Pressure (mmHg) | |||||
| Young | 9.4 (8.9) | 3.36 (5.1) | 7.54 (6.1) | 6.45 (6.1) | |
| Old | 6.36 (8.4) | 5.27 (5.1) | 3.64 (6.1) | 6.18 (6.1) | |
| Pulse (bpm) | Young | 5.6 (3.9) | 16.09 (3.7) | −4.18 (4.2) | −4.45 (4.2) |
| Old | 7.9 (3.7) | 3.5 (3.9) | 1.55 (4.2) | −7.27 (4.2) | |
| Pupil Diameter (mm) 1,2 | Young | −.75 (.2) | −.55 (.2) | −1.68 (.3) | −1.27 (.3) |
| Old | −.14 (.2) | −.10 (.2) | −1.0 (.3) | −.45 (.3) |
1
SCOP analysis age main effect for pupil diameter: F(1,20) = 6.32, p < .05
2
MECA analysis age main effect for pupil diameter: F(1,20) = 4.75, p < .05