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AP-2γ mutant embryos have delayed skin barrier formation. Control embryos (+/+) have established an epidermal barrier by E17.5 as shown by the lack of blue x-gal staining. AP-2γ mutant embryos (−/−) have an incomplete barrier at E17.5 as shown by the uptake of x-gal on the ventral half of the embryo. Bar = 5mm.
