Table 1.

Summary of key features of the patatin-like lipases and CGI-58 from chicken (Gg) and man (Hs).

Name(s)	Chr. location Gg/Hs	Size cDNA (bp) Gg/Hs	Size protein (aa) Gg/Hs	Patatin domain (aa) Gg/Hs	Identity (%) Gg vs. Hs	Accession number mRNA Gg	Accession number mRNA Hs	Function(s)
PNPLA1	26/ 6p21	?/ 1602	?/ 533	15–185/ 16–187	~46	EU419876	89886440	?
PNPLA2 ATGL iPLA2ζ desnutrin TTS-2	5/ 11p15.5	1452/ 1515	483/ 504	10–180/ 10–180	67	EU419874	58759050	TG hydrolysis [12], transacylase [10]
PNPLA3 adiponutrin iPLA2ε	1/ 22q13.31	?/ 1446	?/ 481	?/ 10–180	~49	EU419875	17059635	Lipase [11], transacylase [10]
PNPLA4 iPLA2η GS2	1/ Xp22.3	762/ 762	253/ 253	6–177/ 6–177	76	EU419877	458225	Lipase [11], transacylase [10]
PNPLA5 GS2-like	-/ 22q13	-/ 1290	-/ 429	-/ 12–182	-	-	85397722	Lipase [11]
PNPLA6 NTE	?/ 19p13.3-13.2	?/ 3984	?/ 1327	?/ 933–1100	~83	EU419880	2982500	Lysophospholipid hydrolysis [37], cell signaling [34]
PNPLA7 NTE-related esterase NRE	17/ 9q31.3	3975/ 3954	1324/ 1317	936–1103/ 928–1095	73	EU419881	34531027	Esterase [40], Lysophospho-lipase [39]
PNPLA8 iPLA2γ	1/ 7q31	2412/ 2349	803/ 782	465–661/ 445–640	59	EU419878	7670057	Potential lipase [19]
PNPLA9 PLA2G6 iPLA2β	1/ 22q13.1	2391/ 2421	796/ 806	472–657/ 481–666	62	EU419879	3142699	Lipase [29]
CGI-58 ABHD5	2/ 3p21	1032/ 1050	343/ 349	-	79	EU419873	33469972	Activation of PNPLA2/ATGL [22]

The currently known synonyms for all gene products are listed under Name(s). Chromosomal locations of the genes, size of the cDNAs and proteins (where "?" indicates partial avian sequence), location of the patatin-domain within the proteins, % identities between the chicken and human proteins ("~" is used in cases where partial avian sequence is available), accession numbers of the mRNAs [64], and functions of the proteins where known (functional data from other species are also shown here), are listed with the relevant references. Note that information on the avian PNPLA5 could not be obtained, as described in the text.