Table 3.
HRs (95% CI) for hip fracture according to the plasma B-vitamin group among men and women in the Framingham Study (1987–2003)
| Vitamin | No. | Status group | Multivariable adjusteda | Multivariable and baseline BMD adjusted | Multivariable and homocysteine adjusted |
|---|---|---|---|---|---|
| Folate | 960 | Normal | 1.00 | 1.00 | 1.00 |
| Low | 0.76 (0.43, 1.32) | 0.73 (0.42, 1.28) | 0.72 (0.41, 1.26) | ||
| Deficient | 1.38 (0.91, 2.09) | 1.31 (0.86, 1.98) | 1.20 (0.78, 1.86) | ||
| P for trend | n/a | n/a | n/a | ||
| Vitamin B12 | 823 | Normal | 1.00 | 1.00 | 1.00 |
| Low | 1.48 (0.90, 2.42) | 1.53 (0.93, 2.50) | 1.39 (0.84, 2.29) | ||
| Deficient | 1.89 (1.01, 3.52) | 1.62 (0.86, 3.04) | 1.60 (0.83, 3.10) | ||
| P for trend | 0.02 | 0.06 | 0.10 | ||
| Vitamin B6 | 909 | Normal | 1.00 | 1.00 | 1.00 |
| Low | 1.31 (0.74, 2.34) | 1.19 (0.66, 2.12) | 1.16 (0.64, 2.09) | ||
| Deficient | 1.73 (1.02, 2.95) | 1.54 (0.90, 2.63) | 1.56 (0.90, 2.68) | ||
| P for trend | 0.04 | 0.11 | 0.12 |
n/a, Not applicable.
a
Adjusted for sex, age, height, weight, and estrogen use in women.