Table 4.
Hip fracture HR (95% CI) for high plasma homocysteine concentration (>14 μmol/liter) vs. normal (≥14 μmol/liter), with and without adjustment for plasma B-vitamin concentration among men and women in the Framingham Study (1987–2003)
| Vitamin adjusted for | No. | Homocysteine group | Multivariable adjusteda | Multivariable and B vitamin adjusted |
|---|---|---|---|---|
| None | 979 | Normal | 1.00 | |
| High | 1.69 (1.12, 2.55) | |||
| Folate | 960 | Normal | 1.00 | 1.00 |
| High | 1.74 (1.15, 2.64) | 1.66 (1.08, 2.56) | ||
| Vitamin B12 | 823 | Normal | 1.00 | 1.00 |
| High | 1.70 (1.06, 2.73) | 1.49 (0.91, 2.46) | ||
| Vitamin B6 | 909 | Normal | 1.00 | 1.00 |
| High | 1.75 (1.15, 2.66) | 1.63 (1.06, 2.51) |
a
Adjusted for sex, age, height, weight, and estrogen use in women.