Table 3.

Mutation rates in MMR- and NER-defective strains

Relevant genotype	Canr	Hom+	Lys+
Wild type	2.4  × 10−7 (1)	8.7  × 10−9 (1)	1.0  × 10−8 (1)
rad10	4.7  × 10−7 (1.9)	11.2  × 10−9 (1.3)	1.4  × 10−8 (1.4)
rad2	8.0  × 10−7 (3.2)	7.7  × 10−9 (0.9)	1.6  × 10−8 (1.6)
rad14	5.6  × 10−7 (2.2)	10.5  × 10−9 (1.2)	2.0  × 10−8 (2)
msh2	2.9  × 10−6 (12)	4.5  × 10−6 (517)	7.3  × 10−7 (73)
msh2 rad10	3.7  × 10−6 (15)	5.7  × 10−6 (655)	ND
msh2 rad2	3.3  × 10−6 (13)	4.5  × 10−6 (528)	6.4  × 10−7 (64)
msh2 rad14	2.8  × 10−6 (11.4)	5.0  × 10−6 (580)	5.9  × 10−7 (59)

Mutation rates (inactivation of CAN1 and reversion of hom3-10 or lys2-Bgl) were determined and the mean of 3-5 independent experiments is presented. The numbers in parentheses are the increase in mutation rate observed relative to wild type. The strains used are the strains listed in the legend to Fig. 6. Also see Table 2. ND, not determined.