Figure 1.

(A) Northern blot analysis of NP34 transgene expression in various organs of a Rag-1^−/−Tap-1^−/−NP34⁺ mouse. (B) NP34 is presented in a Tap-1-independent manner. Con A blasts from Tap-1^−/−NP34⁺ mice (•) were assayed for lysis by NP34-specific cytotoxic T cells. As negative and positive controls, Con A blasts from Tap-1^−/− mice incubated with (▴) or without (■) 1 μg/ml synthetic NP34 peptide were used.