Figure 1.

Quantification of atherosclerosis in the aorta of control apoE-deficient mice (white) and mice treated with LU135252 for 30 wk (black). Intimal area of the aortic surface area covered with atheromatous plaques (a) and lesion size in histologic sections of the thoracic aorta (b) were reduced by chronic ET_A receptor blockade. No macroscopic or microscopic lesions were observed in C57BL/6 mice (unpublished observation and ref. 34). P < 0.001 (a) and P < 0.05 (b) for control vs. LU135252.