Figure 2.

Photomicrographs of atherosclerotic lesion in the aortic arch of apoE-deficient mice. Advanced intimal lesion at the root of the carotid artery in an untreated apoE-deficient mouse exhibiting necrosis, calcification, and cholesterol crystals (a). Lesion at the same location in an apoE-deficient mouse after 30 wk of ET_A receptor blockade (b). Cellular composition and morphology of the plaques was similar to that seen in untreated animals. (Elastica van Giesson stain, original magnification X60).