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(a) A time course of ear temperature increase (n=5) in response to a single i.p. niacin (7.5 mg per rat) injection. The increase at all time points was significant (*P=0.0002). (b) Dose–response of the effect of a single i.p. niacin injection on ear temperature increases recorded 45 min later (n=5; *P=0.0001). Niacin rat doses correspond to the doses in an 80 kg human as follows: 5.0 mg per rat=1167 mg per human; 7.5 mg per rat=1750 mg per human; 10 mg per rat=2334 mg per human.
