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Time course of the inhibitory effect of pretreatment with luteolin (4.3 mg per rat). Luteolin was given at the time points shown before, or at the same time as (shown as 0 h), the single i.p. niacin injection (7.5 mg per rat). Increases in ear temperature (n=3) were measured 45 min after niacin treatment. All pretreatments produced statistically significant inhibition, compared to a control rat injected with 0.5 ml olive oil and 7.5 mg niacin (*P<0.001).
